Yes, I gotta say that was a beautiful piece of destruction that was. On that, though - Even the first time entering the Wasteland after the Vault.. I dunno about anyone else but I just had to stand on that cliff overlooking Springvale and just drink in the scenery for a good long time. I was blessed that my computer can handle the heavy resources that just made it look absolutely stunning.
But yeah, there are so many to choose from really, and from each game, too. Some of my choices already being mentioned in the one with the Master with the FEV, and the Overseer from Fallout 1 lol
And it depends whether we're talking random shit, or scripted stuff from the games.. Because, for example, one of my favourite moments was Sulik taking down half of Reno by himself, and then dying violently when a hooker came up and jabbed him with a shiv. Real nice, Sulik.
Never did find his sister, either

From Tactics, I found myself rolling on the floor laughing when a flimsy Ghoul charges at a horde of Super Mutants, and screams "Where's the beef!?" before being gunned down in a hailstorm of bullets and gore.
Anyway, onto the main tamale - Fallout 3. I have so many, but I will list a few that come to mind.
Random event - GW2 (Great War 2). I don't know how the random events spawn, but I was walking through the Wasteland minding my own business, when I hear an explosion, so I of course begin moving towards the red markers in my HUD. I walk over the hill, and I see something of a Warhammer 40k magnitude. Lasers, missiles, and bullets are flying all over the place, as I see Super Mutants, Outcasts - There were Robots too which I THINK were Outcast Robots, a Talon Company squad, a Yao Guai, and even a few Radscorpions, in a massive free for all. Too late for me to hide, I decide to just watch. Fawkes however had other ideas, and upon screaming at the top of his lungs, charged into the thick of it weidling his Super Sledge - Even after specific instructions to use his Gattling Laser. I only wish I recorded it, as I have not seen anything on that scale since.
Also noteworthy was my first encounter with a Behemoth - Not the one at GNR and not the one at Evergreen - just a wild one roaming the countryside. I was only low level, and all I had on me were some small guns such as the HR, a CAR, a Shotty, and such. I was not yet proficient in energy or large weapons or anything. It was insane. One toss of that fire hydrant and I'd get sent flying.. Took a few reloads but I got him in the end lol
Plenty more good times, this is just to name a few
